Flank

At the beginning of battle, if this unit is in the first position, the unit in the second position gains reach.

is a match because Flank gives a melee unit beside Drybone Megalodon a way to reach the backline and Inspire increases not only this unit's melee attack but also that unit’s melee attack. This makes their Flank attacks hit harder and helps break the enemy tank faster. The combo also turns Drybone Megalodon into a great partner for any melee-focused lineup.

is a counter because Since both Drybone Megalodon and the unit benefitting from Flank are melee units. They take Thorns damage every time they hit. This makes Flank much more risky because the attacking unit supported by Flank means taking free damage every swing. Both the unit benefitting from Flank and Drybone Megalodon itself are both melee units and suffers from Thorns.

Retaliate

When hit with a melee attack, Units with retaliate have a 50% chance of immediately attacking their attacker.

is a match because Retaliate can miss if the enemy is fast and has high speed or has Dodge but True Strike makes every counterattack land. When paired together, Drybone Megalodon can consistently deal melee attacks and retaliate with no wasted turns. This gives Drybone Megalodon more value especially in melee matchups where enemies can hit it many times.

is a counter because Dodge increases the chance for incoming melee attacks to miss and Retaliate is still treated like a normal melee hit which would be affected as well. This means Drybone Megalodon can waste normal attacks and many Retaliate triggers on enemies it cannot connect with. In these fights, Retaliate loses a lot of value as it hits the air.

Thorns

When hit with a Melee attack, does 2 Meele damage back to the attacker.

is a match because Amplify increases Thorns damage by 1 which makes every enemy melee hit hurt more. This turns Drybone Megalodon's Thorns into a real danger for any melee attacker trying to break through its armor and health. It also forces enemies to think twice before sending fast but low health melee units into it.

is a counter because Deflect prevents Thorns damage when a melee unit is attacking making Thorns useless against them. This removes one of Drybone Megalodon’s biggest defensive strengths because attackers can now hit safely. When the enemy team has multiple Deflect units, Drybone Megalodon’s Thorns damage disappears.

Aim True

All units gain True Strike (attacks will never miss).

Aim True helps Drybone Megalodon land every melee hit which increases its consistency. This also eliminates any problems with Retaliate. Retaliate also becomes more reliable since missing is no longer possible. This rule lets Drybone Megalodon pressure enemies without worrying about speed or Dodge. The partner with the Flank ability also gains the similar advantage especially since this unit is also melee and can miss. That miss would be important to bring down the enemy frontline fast.

Up to Eleven

All units have Amplify (increases damage of Retaliate and all Punishment abilities—Corrosive Ward, Magic Reflect, Return Fire, and Thorns—by 1; does not stack).

Drybone Megalodon benefits from Amplify because it increases all Thorns damage it returns. This makes enemies suffer more whenever they hit it with melee attacks. The extra damage helps deal with melee tanks and low-health melee units faster. The only regret in this rule is that it does not stack. Even though you have 6 units on the field and all of them have Amplify from Up to Eleven, just take note that Thorns will only increase by 1 and not 1 per Amplify.

Up Close & Personal

Only Units with Melee attack may be used in battles.

Since Drybone Megalodon has Retaliate and Thorns, this rule gives it maximum value. Every attacker hitting it is in a risk and Drybone Megalodon can punish them more often. It turns the whole match into a melee slugfest where Drybone Megalodon reigns supreme. Surprisingly, this rule works best with all of his abilities. The partnered unit with Flank also needs to be a melee unit for Flank to work so Up Close & Personal rule also supports that idea.

Unprotected

Units do not have any armor and do not get armor from Abilities or Summoner Buffs.

Drybone Megalodon relies partly on its armor to survive and keep using Retaliate and Thorns. When armor is removed, its health gets attacked directly, reducing it too fast. This makes it weaker as a front tank and without any abilities that reduce enemy attacks or makes him tankier, this rule really hurts him bad especially when the enemy have a lot of high damaging melee and range units.

Deflection Field

All units have Reflection Shield (0 damage from Blast splash damage and Punishment abilities—Corrosive Ward, Magic Reflect, Return Fire, and Thorns).

Thorns loses all value here since attackers can ignore the returned damage. This makes Drybone Megalodon lose one of its strongest ability. Without thorns, Drybone Megalodon becomes easier to deal with and slightly less scary. On the other hand, only melee units are affected by Thorns so if the enemy used mostly magic attacks, playing in this rule or not still wouldn't matter. I also want to point out that Retaliate does not stop or negate Retaliate effects and its damage.

Briar Patch

All units have Thorns (returns 2 damage to attacker when hit by a melee attack)

Drybone Megalodon having Thorns is normally good, but in this rule, enemies also have Thorns. This punishes Drybone Megalodon’s own attacks and the attacks from its Flank partner. Retaliate also becomes a problem since every counterattack that hit triggers Thorns one more time.